The growth hormone secretagogue receptor (GHSR) signals in response to ghrelin, but also acts via ligand-independent mechanisms that include either constitutive activation or interaction with other G protein-coupled receptors, such as the dopamine 2 receptor (D2R).A key target of GHSR in neurons is voltage-gated calcium channels type 2.2 (CaV2.2).R
Liver fibrosis represents a progressive pathological condition that can culminate in severe hepatic dysfunction, potentially advancing to cirrhosis and liver cancer.The extent of liver fibrosis is intrinsically associated with the synovex one grass quantity of collagen fibers.Although liver biopsy and ultrasound imaging are standard diagnostic tool
Background and ObjectiveVoice disorders are pathological conditions that directly affect voice production.Computer based diagnosis may play a major role in the early detection and in tracking and even development of efficient pathological speech diagnosis, based on a computerized acoustic evaluation.The health of the Voice is assessed by several ac
Abstract Background Allostery is one of the most powerful and common ways of regulation of protein activity.However, for most allosteric proteins identified to date the mechanistic details of allosteric modulation are not yet well understood.Uncovering common mechanistic patterns underlying allostery would allow not only a better academic understan